The region of Garrus, one of the lesser-known areas of western Iran, has played a pivotal role in connecting the economic, cultural, and military networks of the Iranian Plateau, Azerbaijan, and Mesopotamia. This study aims to elucidate the strategic position of Garrus within commercial networks and to analyze its multifaceted economic, military, and cultural functions. Employing a descriptive–analytical method based on library sources and historical documents, the research highlights the region’s natural features—including fertile plains, highlands, and abundant water resources—as key factors in the development of caravan routes and trading centers. Garrus functioned not only as a transit point for goods such as silk, spices, and livestock products but also as a hub of cultural exchange and interethnic interaction due to its location along major trade routes. Furthermore, its fortresses and natural strongholds provided control over vital communication arteries. Ultimately, the study identifies Garrus as a “connective hub” in Iranian history—one whose significance extended far beyond that of a mere trade route.